Novo Nordisk A/S – Share repurchase programme

Bagsværd, Denmark, 5 October 2026 – On 6 May 2026, Novo Nordisk initiated a share repurchase programme in accordance with Article 5 of Regulation No 596/2014 of the European Parliament and Council of 16 April 2014 (MAR) and the Commission Delegated Regulation (EU) 2016/1052 of 8 March 2016 (the "Safe Harbour Rules"). This programme is part of the overall share repurchase programme of up to DKK 15 billion to be executed during a 12-month period beginning 4 February 2026. Under the programme initiated 6 May 2026, Novo Nordisk will repurchase B shares for an amount up to DKK 11,200,000,010.45 in the period from 6 May 2026 to 1 February 2027. Since the announcement 28 September, the following transactions have been made: ──────────────────────────┬───────────────┬──────────────────┬────────────────── │Number of │Average │Transaction │B shares │purchase price │value, DKK ──────────────────────────┼───────────────┼──────────────────┼────────────────── Accumulated, last │20,620,000 │ │6,139,842,042 announcement │ │ │ ──────────────────────────┼───────────────┼──────────────────┼────────────────── 28 September 2026 │245,000 │253.30 │62,059,136 ──────────────────────────┼───────────────┼──────────────────┼────────────────── 29 September 2026 │245,000 │252.74 │61,921,920 ──────────────────────────┼───────────────┼──────────────────┼────────────────── 30 September 2026 │245,000 │250.50 │61,372,450 ──────────────────────────┼───────────────┼──────────────────┼────────────────── 1 October 2026 │245,000 │249.50 │61,126,718 ──────────────────────────┼───────────────┼──────────────────┼────────────────── 2 October 2026 │245,000 │248.77 │60,948,613 ──────────────────────────┼───────────────┼──────────────────┼────────────────── Accumulated under the │21,845,000 │ │6,447,270,879 programme │ │ │ ──────────────────────────┴───────────────┴──────────────────┴────────────────── The details for each transaction made under the share repurchase programme are published on novonordisk.com. With the transactions stated above, Novo Nordisk owns a total of 50,644,876 B shares of DKK 0.10 as treasury shares, corresponding to 1.1% of the share capital. The total amount of A and B shares in the company is 4,465,000,000 including treasury shares. Novo Nordisk expects to repurchase B shares for an amount up to DKK 15 billion during a 12-month period beginning 4 February 2026. As of 2 October 2026, Novo Nordisk has since 4 February 2026 repurchased a total 36,604,179 B shares at an average share price of DKK 279.95 per B share equal to a transaction value of DKK 10,247,270,869. Novo is the global healthcare company that believes lasting health starts now. For over a century, we’ve combined leading scientific expertise with a deep understanding of people’s lives. We develop treatments and support that help millions of people make progress they can see, feel and sustain now and in the future. Every day, over 67,000 employees around the world advance our purpose to drive change for lasting health. Through our partnerships, programmes and investments, we’re working to prevent disease, expand access to treatments and reduce our environmental impact to help even more people live healthier lives. Novo Nordisk's B shares are listed on Nasdaq Copenhagen (Novo-B). Its ADRs are listed on the New York Stock Exchange (NVO). For more information, visit novonordisk.com and follow us on Instagram, LinkedIn, TikTok, Facebook, X and YouTube. Contacts for further information ────────────────────────────────────────┬─────────────────────────────────────── Novo Nordisk Media: │ ────────────────────────────────────────┼─────────────────────────────────────── Ambre James-Brown │Liz Skrbkova (US) +45 3079 9289 │+1 609 917 0632 globalmedia@novonordisk.com │USMediaRelations@novonordisk.com ────────────────────────────────────────┼─────────────────────────────────────── Novo Nordisk Investors: │ ────────────────────────────────────────┼─────────────────────────────────────── Michael Novod │Sina Meyer +45 3075 6050 │+45 3079 6656 nvno@novonordisk.com │azey@novonordisk.com ────────────────────────────────────────┼─────────────────────────────────────── Christoffer Togo Solgaard-Tullin │Max Ung +45 3079 1471 │+45 3077 6414 cftu@novonordisk.com │mxun@novonordisk.com ────────────────────────────────────────┼─────────────────────────────────────── Ida Schaap Melvold │Mads Berner Bruun +45 3077 5649 │+45 3075 2936 idmg@novonordisk.com │mbbz@novonordisk.com ────────────────────────────────────────┼─────────────────────────────────────── Frederik Taylor Pitter (US) │Alex Bruce (US) +1 609 613 0568 │+1 640 230 0276 fptr@novonordisk.com │axeu@novonordisk.com ────────────────────────────────────────┴─────────────────────────────────────── Company announcement No 60 / 2026 Attachments CA261005_Safe Harbour CA261005_Safe harbour transaction details [1]: https://www.globenewswire.com/Tracker?data=938eIUhZFKf0j0Z_794-zEEvSIRjksMF zntMevySbE9za8iWcA1IzAaPTHU12c8UjNnStTT2iK-Hx6wLP6ZoqiZZ0ucsTr0WGcPFwUL56LxrTA41 yqdYnwFsX9dcZLrXWZ19p163Y137NYfGrOY0uad_4ZNvBApgbg5FnBZoKVY= [2]: https://www.globenewswire.com/Tracker?data=938eIUhZFKf0j0Z_794-zNrSzUs7mind R1YzXqa8adjuINcd1ZXMzob6OP5iq2ZbGIp8S242GlkYSsTuE3QH-Isl0J2X4AXycJVN-TXdLOY= [3]: https://www.globenewswire.com/Tracker?data=h6O2DMprbtSPXnaWpZHdqmZAPN-ubr7X CrGILIHrbwMy7yVZAwHy7rXMxx9X2bkf2zUwQ3L6Qml6T5F469ukd1SIP51SpYSOn31h583VtLY= [4]: https://www.globenewswire.com/Tracker?data=sBzLgVc4bLK185xvPDh_0v6Mm70Sneye qi9aNwjzfkyxLJDsGEoaMBSbPiBHGlmarqj93mJlDSst7Cf6ZVlqjB4gN65p9F3_S4RhDsBmMN8f48-r yRzjujb_PqdwXbRh [5]: https://www.globenewswire.com/Tracker?data=2kk_NgPF7-yxsBE4i5NBO4xwyyoKkAvm m7PEy5Dj1U4Li6NF-wnAxmJ-ziRL997vXWB422mj4643hE8jOq8zX9G4_lxOqYKA-0qB-K3CbbE= [6]: https://www.globenewswire.com/Tracker?data=WOKWIq6VMMvD45954LXKi2BDAsKuqdQM S5vUl21eXY_-8kSgZgnZMQ080ZIHK0rmRpHL6qRQSiBe7HQcpc8P6q3fXetP4Ksg9PEkklKa6jk= [7]: https://www.globenewswire.com/Tracker?data=t3LqyZsBvbePdUFSMcwk2bRpx4m7xWVu Yo1Q2fa1mtYBJDn2TnRWcJ9ZxrvCsUmJyQC38X2RxnENcPqMJ074NA== [8]: https://www.globenewswire.com/Tracker?data=G3BQ4ir3tHeyR7XdiWnoK8HAyEC0Y9aw 9y2_Ez2PqcRyWkhvsUDeMpneWKyV_D9goAvqizBwiETV3u_etFjeOI6hfjtqZrcDxu4se_XabRE= [9]: mailto:globalmedia@novonordisk.com, [10]: mailto:USMediaRelations@novonordisk.com [11]: mailto:nvno@novonordisk.com [12]: mailto:azey@novonordisk.com [13]: mailto:cftu@novonordisk.com [14]: mailto:idmg@novonordisk.com [15]: mailto:idmg@novonordisk.com [16]: mailto:mbbz@novonordisk.com [17]: mailto:fptr@novonordisk.com [18]: mailto:axeu@novonordisk.com [19]: https://ml-eu.globenewswire.com/Resource/Download/fbffb2c1-b88b-4b13-8f89- d77cfd5a3d47 [20]: https://ml-eu.globenewswire.com/Resource/Download/75dcf6c8-ec49-449a-8738- 7ae6149b0a6d